One of the main tools I use to remove Malware, Spyware and Virus', besides a good antivirus, is the Malwarebytes product. It comes in two forms, the free version and the paid, pro version.
For the home user, the free version is a great tool for when you 'suspect' that something funny is going on. Maybe you're getting an odd pop-up in your web browser you don't expect, or some of your applications have had some odd behaviors. If that's the case, then the free version will help you ferret out any Malware issues you may have.
Installation is very straight forward, as detailed by Malwarebytes own Installation Video.
If you're in real trouble, you can boot your system in Safe Mode with Networking (Windows 7 version of Safe Mode with Networking) and run, or install and run this product. Doing a full scan may take a while, however the average quick-scan only takes about 10 minutes. But, if you suspect something is 'hinky', you should definitely take the time to run the full scan.
MajorGeeks has done a bit of a Video Tutorial and review showing how to use the product, and they've done an excellent job showing how the product works.
The think to remember between the free and pro versions is that with the pro version you get more automation while the free version is all manual, and there are some added pro-active protection options with the pro version. All-in-all, this is an excellent product that I would highly recommend having around, just in case.